The immune response to AIDS virus infectivon: good, bad, or both?

被引：64

作者：

Deeks, SG

Walker, BD ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Div AIDS, Boston, MA 02114 USA

[4] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 06期

关键词：

D O I：

10.1172/JCI200421318

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A potent antigen-specific T cell response to HIV infection can contribute to the control of viral replication and is therefore beneficial to the host. However, HIV-mediated increases in generalized T cell activation also appear to accelerate both viral replication and CD4+ T cell depletion. A new study in the JCI attempts to experimentally distinguish the beneficial versus harmful aspects of this immune response (see the related article beginning on page 836).

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页码：808 / 810

页数：3

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