Effects of SR 48692 on neurotensin-induced calcium-activated chloride currents in the Xenopus oocyte expression system: Agonist-like activity on the levocabastine-sensitive neurotensin receptor and absence of antagonist effect on the levocabastine insensitive neurotensin receptor

被引：38

作者：

Botto, JM ^{[1
]}

Guillemare, E ^{[1
]}

Vincent, JP ^{[1
]}

Mazella, J ^{[1
]}

机构：

[1] UNIV NICE,INST PHARMACOL MOL & CELLULAIRE,CNRS,UPR 411,F-06560 VALBONNE,FRANCE

来源：

NEUROSCIENCE LETTERS | 1997年 / 223卷 / 03期

关键词：

neurotensin; SR; 48692; levocabastine; receptor; Xenopus oocytes;

D O I：

10.1016/S0304-3940(97)13437-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the drug SR 48692 on the Ca2+-activated Cl- current induced by neurotensin on Xenopus oocytes injected with cRNAs encoding rodent high and low affinity neurotensin receptors, was examined. In this receptor expression system, SR 48692 failed to antagonize electrophysiological measurement of neurotensin-evoked current via the rat high affinity neurotensin receptor, whereas its application onto oocytes expressing the mouse low affinity neurotensin receptor triggered an inward current, as well as neurotensin itself. However, no current activation was observed after application of the drug on oocytes expressing the rat high affinity neurotensin receptor. These observations in the oocyte expression system did not reflect typical antagonist properties of SR 48692 drug. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：193 / 196

页数：4

共 12 条

[1]

CARRAWAY R, 1973, J BIOL CHEM, V248, P6854

[2]

CHABRY J, 1994, J NEUROCHEM, V63, P19

[3] Molecular cloning of a levocabastine-sensitive neurotensin binding site [J].

Chalon, P ;

Vita, N ;

Kaghad, M ;

Guillemot, M ;

Bonnin, J ;

Delpech, B ;

LeFur, G ;

Ferrara, P ;

Caput, D .

FEBS LETTERS, 1996, 386 (2-3) :91-94

[4] THE NONPEPTIDE NEUROTENSIN ANTAGONIST, SR-48692 USED AS A TOOL TO REVEAL PUTATIVE NEUROTENSIN RECEPTOR SUBTYPES [J].

DUBUC, I ;

COSTENTIN, J ;

TERRANOVA, JP ;

BARNOUIN, MC ;

SOUBRIE, P ;

LEFUR, G ;

ROSTENE, W ;

KITABGI, P .

BRITISH JOURNAL OF PHARMACOLOGY, 1994, 112 (02) :352-354

[5] BIOCHEMICAL AND PHARMACOLOGICAL PROFILE OF A POTENT AND SELECTIVE NONPEPTIDE ANTAGONIST OF THE NEUROTENSIN RECEPTOR [J].

GULLY, D ;

CANTON, M ;

BOIGEGRAIN, R ;

JEANJEAN, F ;

MOLIMARD, JC ;

PONCELET, M ;

GUEUDET, C ;

HEAULME, M ;

LEYRIS, R ;

BROUARD, A ;

PELAPRAT, D ;

LABBEJULLIE, C ;

MAZELLA, J ;

SOUBRIE, P ;

MAFFRAND, JP ;

ROSTENE, W ;

KITABGI, P ;

LEFUR, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :65-69

[6]

LABBEJULLIE C, 1995, MOL PHARMACOL, V47, P1050

[7] CDNA CLONING OF BOVINE SUBSTANCE-K RECEPTOR THROUGH OOCYTE EXPRESSION SYSTEM [J].

MASU, Y ;

NAKAYAMA, K ;

TAMAKI, H ;

HARADA, Y ;

KUNO, M ;

NAKANISHI, S .

NATURE, 1987, 329 (6142) :836-838

[8]

Mazella J, 1996, J NEUROSCI, V16, P5613

[9] THE NONPEPTIDE NEUROTENSIN RECEPTOR ANTAGONIST SR48692 IS NOT A POTENT ANTAGONIST OF NEUROTENSIN(8-13) RESPONSES OF RAT SUBSTANTIA-NIGRA NEURONS IN-VITRO [J].

PINNOCK, RD ;

WOODRUFF, GN .

NEUROSCIENCE LETTERS, 1994, 172 (1-2) :175-178

[10] STRUCTURE AND FUNCTIONAL EXPRESSION OF THE CLONED RAT NEUROTENSIN RECEPTOR [J].

TANAKA, K ;

MASU, M ;

NAKANISHI, S .

NEURON, 1990, 4 (06) :847-854

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