Idiopathic, immune, infectious, and idiosyncratic neutropenias

被引：31

作者：

Palmblad, JEW ^{[1
]}

von dem Borne, AEGK

机构：

[1] Huddinge Univ Hosp, Dept Med M54, Karolinska Inst, SE-14186 Stockholm, Sweden

[2] Huddinge Univ Hosp, Dept Hematol, Karolinska Inst, SE-14186 Stockholm, Sweden

[3] Univ Amsterdam, Acad Med Ctr, Dept Hematol, NL-1105 AZ Amsterdam, Netherlands

来源：

SEMINARS IN HEMATOLOGY | 2002年 / 39卷 / 02期

关键词：

D O I：

10.1053/shem.2002.31919

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In idiopathic and immune neutropenias the susceptibility to infectious agents is highly variable, but the reason why some patients exhibit no undue susceptibility whereas others contract life-threatening infections is poorly understood. An important factor is the efficacy of delivery of neutrophils to the tissues. Recent investigations of the mechanisms for mild to moderate chronic neutropenias have shown the significance of interactions between myelopoiesis and the immune system, as for example, in relation to immunoglobulin aberrations and the cytokine network. Antibody-mediated neutropenias (alloimmune, autoimmune) are now well-characterized diseases. If infections occur, apart from antibiotics, granulocyte colony-stimulating factor (G-CSF) is the treatment of choice, while intravenous or monoclonal immunoglobulins and cyclosporine are reserved for refractory cases. Copyright 2002, Elsevier Science (USA). All rights reserved.

引用

页码：113 / 120

页数：8

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