Nucleophilic difluoromethylation and difluoromethylenation of aldehydes and ketones using diethyl difluoromethylphosphonate

被引：47

作者：

Beier, Petr ^{[1
]}

Alexandrova, Anastasia V. ^{[1
]}

Zibinsky, Mikhail ^{[2
]}

Prakash, G. K. Surya ^{[2
]}

机构：

[1] Acad Sci Czech Republic, Inst Organ Chem & Biochem, CR-16610 Prague 6, Czech Republic

[2] Univ So Calif, Dept Chem, Loker Hydrocarbon Res Inst, Los Angeles, CA 90089 USA

来源：

TETRAHEDRON | 2008年 / 64卷 / 49期

关键词：

Difluoromethylation; Difluoromethylenation; Phosphonate; Nucleophilic addition;

D O I：

10.1016/j.tet.2008.10.006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New methodology for difluoromethylation and difluoromethylenation of aldehydes and ketones based On nucleophilic fluorination using diethyl difluoromethylphosphonate (1) was developed (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：10977 / 10985

页数：9

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