Human immune system variation

被引：508

作者：

Brodin, Petter ^{[1
,2
]}

Davis, Mark M. ^{[3
,4
,5
]}

机构：

[1] Karolinska Inst, Dept Med Solna, Sci Life Lab, S-17165 Stockholm, Sweden

[2] Karolinska Univ Hosp, Dept Neonatol, S-14186 Stockholm, Sweden

[3] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94304 USA

[4] Stanford Univ, Sch Med, Inst Immun Transplantat & Infect, Stanford, CA 94304 USA

[5] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94304 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2017年 / 17卷 / 01期

基金：

欧洲研究理事会; 瑞典研究理事会;

关键词：

DELTA T-CELLS; MASS CYTOMETRY; RHEUMATOID-ARTHRITIS; CIRCADIAN-RHYTHMS; PERIPHERAL-BLOOD; SEX-DIFFERENCES; EXPRESSION; DISEASE; AUTOIMMUNE; MICROBIOTA;

D O I：

10.1038/nri.2016.125

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The human immune system is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled systems immunology analyses, which reveal the composition of immune cells and proteins in populations of healthy individuals. The range of variation and some specific influences that shape an individual's immune system is now becoming clearer. Human immune systems vary as a consequence of heritable and non-heritable influences, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation. Understanding when and how such influences shape the human immune system is key for defining metrics of immunological health and understanding the risk of immune-mediated and infectious diseases.

引用

页码：21 / 29

页数：9

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