Regulatory T cells overexpress a subset of Th2 gene transcripts

被引:143
作者
Zelenika, D [1 ]
Adams, E [1 ]
Humm, S [1 ]
Graca, L [1 ]
Thompson, S [1 ]
Cobbold, SP [1 ]
Waldmann, H [1 ]
机构
[1] Sir William Dunn Sch Pathol, Therapeut Immunol Grp, Oxford OX1 3RE, England
关键词
D O I
10.4049/jimmunol.168.3.1069
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
There is now compelling evidence for subpopulations of CD4(+) T cells whose role is to prevent immune pathology in both autoimmunity and transplantation. We have cloned CD4(+) T cells against a male transplantation Ag that, unlike Th1 or Th2 clones, suppresses the rejection of male skin grafts and are therefore considered examples of regulatory T cells. We have identified, using serial analysis of gene expression, transcripts that are overexpressed in regulatory T cells compared with Th1 and Th2 clones. Some of these transcripts are increased in tolerated rather than rejecting skin grafts and in addition are expressed by the natural regulatory CD4(+)CD25(+) subpopulation of naive mice. These genes include prepro-enkephalin, GM2 ganglioside activator protein, glucocorticoid-induced TNFR superfamily member 18, and integrin alpha(E)beta(7). They seem to represent a subset of transcripts shared with Th2 cells, suggesting that transplantation tolerance and normal immunoregulation may represent a unique form of Th2-like differentiation.
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收藏
页码:1069 / 1079
页数:11
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