Trifluoromethylation of Allylsilanes under Photoredox Catalysis

被引：119

作者：

Mizuta, Satoshi ^{[1
]}

Engle, Keary M. ^{[1
]}

Verhoog, Stefan ^{[1
]}

Galicia-Lopez, Oscar ^{[1
]}

O'Duill, Miriam ^{[1
]}

Medebielle, Maurice ^{[2
]}

Wheelhouse, Katherine ^{[3
]}

Rassias, Gerasimos ^{[3
]}

Thompson, Amber L. ^{[1
]}

Gouverneur, Veronique ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

[2] Univ Lyon 1, F-69622 Villeurbanne, France

[3] GlaxoSmithKline Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

ORGANIC-SYNTHESIS; TERMINAL ALKENES; LIGHT; EFFICIENT; SILICON;

D O I：

10.1021/ol400184t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new catalytic method to access allylic secondary CF3 products is described. These reactions use the visible light excited Ru(bpy)(3)Cl-2 center dot 6H(2)O catalyst and the Togni or Umemoto reagent as the CF3 source. The photoredox catalytic manifold delivers enantioenriched allylic trifluoromethylated products not accessible under Cu(I) catalysis.

引用

页码：1250 / 1253

页数：4

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