Expression of oligodendrocyte progenitor cell antigens by gliomas:: Implications for the histogenesis of brain tumors

被引:151
作者
Shoshan, Y
Nishiyama, A
Chang, AS
Mörk, S
Barnett, GH
Cowell, JK
Trapp, BD
Staugaitis, SM
机构
[1] Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA
[2] Cleveland Clin Fdn, Dept Neurosurg, Cleveland, OH 44195 USA
关键词
D O I
10.1073/pnas.96.18.10361
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The early events in neoplastic transformation can be understood only by comparison of the neoplastic cell with its nontransformed counterpart. The most common central nervous system gliomas traditionally are thought to arise from mature astrocytes and oligodendrocytes. We examined the possibility that gliomas arise from a population of glia that has properties of oligodendrocyte progenitors. These glial cells express the NG2 chondroitin sulfate proteoglycan and the cw receptor of platelet-derived growth factor in vivo. We identified NG2 and the cw receptor of platelet-derived growth factor expression in tissue from seven of seven oligodendrogliomas, three of three pilocytic astrocytomas, and one of five glioblastoma multiforme. These data provide evidence that glial tumors arise from glial progenitor cells. Molecules expressed by these progenitor cells should be considered as targets for novel therapeutics.
引用
收藏
页码:10361 / 10366
页数:6
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