2-deoxy-2-[18F]fluoro-D-glucose and alternative radiotracers for positron emission tomography Imaging using the human brain as a model

被引：6

作者：

Fowler, JS ^{[1
]}

Volkow, ND

Wang, GJ

Ding, YS

机构：

[1] Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA

[2] NIDA, Bethesda, MD 20892 USA

来源：

SEMINARS IN NUCLEAR MEDICINE | 2004年 / 34卷 / 02期

关键词：

D O I：

10.1053/j.semnuclmed.2004.01.002

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

2-Deoxy-2-[F-18]fluoro-D-glucose ((18)FDG) is now routinely available in many hospitals and other institutions either via on-site production or from one of the dozens of regional radiopharmacies worldwide. Its reliable production has opened the possibility for use in both basic and clinical investigations and also in pairing it with other more biologically specific positron emission tomography tracers to provide an important functional perspective to the measurement. In this article, we highlight examples in which (18)FDG is paired with another carbon-11- or fluorine-18-labeled radiotracer in the same subject to correlate neurotransmitter-specific effects with regional metabolic effects using the human brain as a model. We describe studies that fall into three major areas: normal aging, neuropsychiatric disorders, and drug action. (C) 2004 Elsevier Inc. All rights reserved.

引用

收藏

页码：112 / 121

页数：10

相关论文

共 62 条

[1] SPECT brain perfusion abnormalities in mild or moderate traumatic brain injury [J].

Abdel-Dayem, HM ;

Abu-Judeh, H ;

Kumar, M ;

Atay, S ;

Naddaf, S ;

El-Zeftawy, H ;

Luo, JQ .

CLINICAL NUCLEAR MEDICINE, 1998, 23 (05) :309-317

[2] Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for β-amyloid plaques in Alzheimer's disease [J].

Agdeppa, ED ;

Kepe, V ;

Liu, J ;

Flores-Torres, S ;

Satyamurthy, N ;

Petric, A ;

Cole, GM ;

Small, GW ;

Huang, SC ;

Barrio, JR .

JOURNAL OF NEUROSCIENCE, 2001, 21 (24) :art. no.-RC189

[3] Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease [J].

Antonini, A ;

Leenders, KL ;

Vontobel, P ;

Maguire, RP ;

Missimer, J ;

Psylla, M ;

Günther, I .

BRAIN, 1997, 120 :2187-2195

[4] MONOAMINE-OXIDASE, BRAIN AGING AND DEGENERATIVE DISEASES [J].

BENEDETTI, MS ;

DOSTERT, P .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (04) :555-561

[5]

Bignami Amico, 1995, P843

[6] BRAIN NEUROTRANSMITTERS IN AGING AND DEMENTIA - SIMILAR CHANGES ACROSS DIAGNOSTIC DEMENTIA GROUPS [J].

CARLSSON, A .

GERONTOLOGY, 1987, 33 (3-4) :159-167

[7] Monoamine oxidase and mitochondrial respiration [J].

Cohen, G ;

Kesler, N .

JOURNAL OF NEUROCHEMISTRY, 1999, 73 (06) :2310-2315

[8] THE METABOLIC ANATOMY OF PARKINSONS-DISEASE - COMPLEMENTARY [F-18] FLUORODEOXYGLUCOSE AND [F-18] FLUORODOPA POSITRON EMISSION TOMOGRAPHIC STUDIES [J].

EIDELBERG, D ;

MOELLER, JR ;

DHAWAN, V ;

SIDTIS, JJ ;

GINOS, JZ ;

STROTHER, SC ;

CEDARBAUM, J ;

GREENE, P ;

FAHN, S ;

ROTTENBERG, DA .

MOVEMENT DISORDERS, 1990, 5 (03) :203-213

[9] Multitracer study with positron emission tomography in Creutzfeldt-Jakob disease [J].

Engler, H ;

Lundberg, PO ;

Ekbom, K ;

Nennesmo, I ;

Nilsson, A ;

Bergström, M ;

Tsukada, H ;

Hartvig, P ;

Långström, B .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2003, 30 (01) :85-95

[10]

Fowler JS, 1999, J NUCL MED, V40, P1154

← 1 2 3 4 5 6 7 →