Review of immune-related adverse events in prostate cancer patients treated with ipilimumab: MD Anderson experience

被引：54

作者：

Gao, J. ^{[1
]}

He, Q. ^{[1
]}

Subudhi, S. ^{[1
]}

Aparicio, A. ^{[1
]}

Zurita-Saavedra, A. ^{[1
]}

Lee, D. H. ^{[1
]}

Jimenez, C. ^{[2
]}

Suarez-Almazor, M. ^{[3
]}

Sharma, P. ^{[1
,4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Gen Internal Med, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

ONCOGENE | 2015年 / 34卷 / 43期

关键词：

LYMPHOCYTE-ASSOCIATED ANTIGEN-4; DOSE-ESCALATION TRIAL; REGULATORY T-CELLS; STAGE-IV MELANOMA; METASTATIC MELANOMA; CTLA-4; BLOCKADE; AUTOIMMUNE HYPOPHYSITIS; MONOCLONAL-ANTIBODY; ANTI-CTLA-4; THERAPY;

D O I：

10.1038/onc.2015.5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Targeting a T-cell inhibitory checkpoint with the anti-CTLA-4 monoclonal antibody, ipilimumab, represents a scientific breakthrough in immunotherapy for the treatment of cancer. However, ipilimumab therapy is also associated with unique side effects, known as immune-related adverse events (irAEs), which need to be recognized and managed with immunosuppressive agents. To date, the majority of our knowledge regarding ipilimumab-associated side effects is based upon clinical studies in melanoma. Here we provide a review of ipilimumab-induced irAEs and our experience in a cohort of 44 patients with prostate cancer who were treated at the MD Anderson Cancer Center on two different clinical trial protocols.

引用

页码：5411 / 5417

页数：7

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