X-ray structure of influenza virus NS1 effector domain

被引：84

作者：

Bornholdt, Zachary A.

Prasad, B. V. Venkataram

机构：

[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 06期

关键词：

D O I：

10.1038/nsmb1099

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nonstructural protein NS1 of influenza virus is an antagonist of host immune responses and is implicated in virulence. It has two domains, an N-terminal double-stranded RNA-binding domain (RBD) and an effector domain crucial for RBD function, for nuclear export and for sequestering messenger RNA-processing proteins. Here we present the crystallographic structure of the effector domain, which has a novel fold and suggests mechanisms for increased virulence in H5N1 strains.

引用

页码：559 / 560

页数：2

共 18 条

[1] A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice
Donelan, NR
Basler, CF
García-Sastre, A
[J]. JOURNAL OF VIROLOGY, 2003, 77 (24) : 13257 - 13266
[2] Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes
Ferko, B
Stasakova, J
Romanova, J
Kittel, C
Sereinig, S
Katinger, H
Egorov, A
[J]. JOURNAL OF VIROLOGY, 2004, 78 (23) : 13037 - 13045
[3] Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems
García-Sastre, A
Egorov, A
Matassov, D
Brandt, S
Levy, DE
Durbin, JE
Palese, P
Muster, T
[J]. VIROLOGY, 1998, 252 (02) : 324 - 330
[4] 2 NUCLEAR LOCATION SIGNALS IN THE INFLUENZA-VIRUS NS1 NONSTRUCTURAL PROTEIN
GREENSPAN, D
PALESE, P
KRYSTAL, M
[J]. JOURNAL OF VIROLOGY, 1988, 62 (08) : 3020 - 3026
[5] DaliLite workbench for protein structure comparison
Holm, L
Park, J
[J]. BIOINFORMATICS, 2000, 16 (06) : 566 - 567
[6] Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein
Krug, RM
Yuan, WM
Noah, DL
Latham, AG
[J]. VIROLOGY, 2003, 309 (02) : 181 - 189
[7] Lamb RA, 2001, FIELDS VIROLOGY, P1487, DOI DOI 10.1038/CR.2017.129
[8] Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing
Li, WX
Li, HW
Lu, R
Li, F
Dus, M
Atkinson, P
Brydon, EWA
Johnson, KL
García-Sastre, A
Ball, LA
Palese, P
Ding, SW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (05) : 1350 - 1355
[9] Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses
Lipatov, AS
Andreansky, S
Webby, RJ
Hulse, DJ
Rehg, JE
Krauss, S
Perez, DR
Doherty, PC
Webster, RG
Sangster, MY
[J]. JOURNAL OF GENERAL VIROLOGY, 2005, 86 : 1121 - 1130
[10] Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein
Liu, JS
Lynch, PA
Chien, CY
Montelione, GT
Krug, RM
Berman, HM
[J]. NATURE STRUCTURAL BIOLOGY, 1997, 4 (11) : 896 - 899

← 1 2 →