Catalytic activation of trichlorosilane for efficient and stereoselective reduction of ketones

被引：69

作者：

Iwasaki, F

Onomura, O

Mishima, K

Maki, T

Matsumura, Y

机构：

[1] Kyushu Univ, Inst Fundamental Res Organ Chem, Higashi Ku, Fukuoka 8128151, Japan

[2] Tokuyama Corp, Tsukuba Res Lab, Tsukuba, Ibaraki 3004247, Japan

[3] Nagasaki Univ, Fac Pharmaceut Sci, Nagasaki 8528521, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 42期

关键词：

asymmetric reaction; reduction; silicon halides; ketones; substituent effects;

D O I：

10.1016/S0040-4039(99)01554-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Some kinds of N-formyl cyclic amine derivatives were found to be effective activators for trichlorosilane to reduce ketones. Namely, a catalytic amount of these activators were sufficient to complete the reduction of ketones with trichlorosilane, and the reduction of ketones by trichlorosilane with optically active activators gave enantiomerically enriched sec-alcohols in some extent of optical yields (up to 51% ee). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7507 / 7511

页数：5