Synthesis of trans-vaccenic acid and cis-9-trans-11-conjugated linoleic acid

被引：22

作者：

Duffy, PE

Quinn, SM

Roche, HM

Evans, P ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland

[2] Inst Mol Med, Dept Clin Med, Nutrigenom Res Grp, St James Hosp, Dublin 8, Ireland

来源：

TETRAHEDRON | 2006年 / 62卷 / 20期

关键词：

D O I：

10.1016/j.tet.2006.03.006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of the monounsaturated fatty acid, trans-vaccenic acid 4 (TVA), using both Wittig and one-pot Julia-Kocienski olefination protocol, was achieved in good yield. Similarly a Wittig approach was employed for the stereoselective synthesis of cis-9-trans-11-conjugated linoleic acid 2 from trans-2-nonenal and (8-carboxyoctyl)triphenylphosphonium bromide 12. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：4838 / 4843

页数：6

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