Significant enhancement of antitumor activity and bioavailability of intracellular pH-sensitive polymeric micelles by folate conjugation

被引:13
作者
Bae, Y. [1 ]
Kataoka, K. [1 ,2 ]
机构
[1] Univ Tokyo, Div Clin Biotechnol, Ctr Dis Biol & Integrat Med, Grad Sch Med,Bunkyo Ku, Tokyo 1130033, Japan
[2] Univ Tokyo, Dept Mat Engn, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan
关键词
D O I
10.1016/j.jconrel.2006.09.044
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
027
引用
收藏
页码:E49 / E50
页数:3
相关论文
共 5 条
[1]  
Bae Y, 2005, MOL BIOSYST, V1, P242, DOI 10.1039/b500266d
[2]   Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change [J].
Bae, Y ;
Fukushima, S ;
Harada, A ;
Kataoka, K .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (38) :4640-4643
[3]   Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: Tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy [J].
Bae, Y ;
Nishiyama, N ;
Fukushima, S ;
Koyama, H ;
Yasuhiro, M ;
Kataoka, K .
BIOCONJUGATE CHEMISTRY, 2005, 16 (01) :122-130
[4]   The dawning era of polymer therapeutics [J].
Duncan, R .
NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (05) :347-360
[5]  
Nishiyama Nobuhiro, 2005, Drug Discov Today Technol, V2, P21, DOI 10.1016/j.ddtec.2005.05.007