Minocycline-loaded cellulose nano whiskers/poly(sodium acrylate) composite hydrogel films as wound dressing

In this work, antibiotic drug Minocycline (Mic) loaded cellulose nano-whiskers (CNWs)/poly(sodium acrylate) hydrogel films were prepared and investigated for their drug releasing capacity in physiological buffer solution (PBS) at 37 degrees C. The (CNWs)/poly(sodium acrylate) film, containing 9.7% (w/w) of CNWs, demonstrated Mic release of 2500 mu g/g while the plain poly(acrylate) film showed 3100 mu g/g of drug release. In addition, with the increase in the concentration of cross-linker N,N'-methylene bisacrylamide (MB) from to, the drug release from the resulting films decreased from 507 to 191 mu g/g. The release exponent 'n' for films with different compositions was found in the range of 0.45 to 0.89, thus indicating non-Fickian release mechanism. The Schott model was employed to interpret the kinetic drug release data successfully. The film samples poly(SA) and CNWs/poly(SA) (both not containing drug) showed thrombus formation of 0.010 +/- 0.001 g and 0.007 +/- 0.001 g, respectively, thus showing the non-thrombogenic behavior. In percent Hemolysis, both of the film samples of 1.136 +/- 0.012 and 0.5 +/- 0.020, respectively, thus indicating non-hemolytic behavior. In addition, both of the film samples demonstrated protein adsorption of 49.02 +/- 0.59 mu g/mu L and 51.20 +/- 0.51 mu g/mu L, per cm(2), thus revealing a fair degree of protein adsorption. Finally, the Mic-loaded films showed fair anti-fungal and antibacterial properties. (C) 2015 Elsevier B.V. All rights reserved.