Chitosan-PVP-nano silver oxide wound dressing: In vitro and in vivo evaluation

被引：303

作者：

Archana, D. ^{[1
]}

Singh, Brijesh K. ^{[1
]}

Dutta, Joydeep ^{[2
]}

Dutta, P. K. ^{[1
]}

机构：

[1] MN Natl Inst Technol, Dept Chem, Allahabad 211004, Uttar Pradesh, India

[2] Amity Univ, Sch Appl Sci, Gurgaon Manesar 122413, Haryana, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2015年 / 73卷

关键词：

Chitosan; PVP; Silver oxide; Wound dressing; ESCHERICHIA-COLI; ANTIBACTERIAL PROPERTIES; NANOPARTICLES; ALGINATE; POLYMER; BLENDS; IONS;

D O I：

10.1016/j.ijbiomac.2014.10.055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The main aim of this work was to prepare wound healing material with chitosan, poly vinyl pyrrolidone (PVP), silver oxide nanoparticles. The prepared chitosan, chitosan-PVP-nano silver oxide (CPS) films were characterized for their thermal behaviour, morphological properties, mechanical properties, antibacterial properties and wound healing properties. The CPS film found higher antibacterial activity because the materials both chitosan as well as silver oxide poses good antibacterial activity. L929 cell lines were for cytotoxicity study and Adult male albino rats (140-180 g) were used for wound healing study. The prepared film has more wound healing property than of cotton gauge, 100% chitosan and other reported chitosan based dressings. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：49 / 57

页数：9

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