Chitosan-PVP-nano silver oxide wound dressing: In vitro and in vivo evaluation

被引：303

作者：

Archana, D. ^{[1
]}

Singh, Brijesh K. ^{[1
]}

Dutta, Joydeep ^{[2
]}

Dutta, P. K. ^{[1
]}

机构：

[1] MN Natl Inst Technol, Dept Chem, Allahabad 211004, Uttar Pradesh, India

[2] Amity Univ, Sch Appl Sci, Gurgaon Manesar 122413, Haryana, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2015年 / 73卷

关键词：

Chitosan; PVP; Silver oxide; Wound dressing; ESCHERICHIA-COLI; ANTIBACTERIAL PROPERTIES; NANOPARTICLES; ALGINATE; POLYMER; BLENDS; IONS;

D O I：

10.1016/j.ijbiomac.2014.10.055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The main aim of this work was to prepare wound healing material with chitosan, poly vinyl pyrrolidone (PVP), silver oxide nanoparticles. The prepared chitosan, chitosan-PVP-nano silver oxide (CPS) films were characterized for their thermal behaviour, morphological properties, mechanical properties, antibacterial properties and wound healing properties. The CPS film found higher antibacterial activity because the materials both chitosan as well as silver oxide poses good antibacterial activity. L929 cell lines were for cytotoxicity study and Adult male albino rats (140-180 g) were used for wound healing study. The prepared film has more wound healing property than of cotton gauge, 100% chitosan and other reported chitosan based dressings. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：49 / 57

页数：9

共 54 条

[41]

Raffi M, 2008, J MATER SCI TECHNOL, V24, P192

[42] Chitosan polymer as biloactive coating and film against Aspergillus niger contamination [J].

Sebti, I ;

Martial-Gros, A ;

Carnet-Pantiez, A ;

Grelier, S ;

Coma, V .

JOURNAL OF FOOD SCIENCE, 2005, 70 (02) :M100-M104

[43] Preparation of water soluble chitosan blendmers and their application to removal of heavy metal ions from wastewater [J].

Seo, SB ;

Kajiuchi, T ;

Kim, DI ;

Lee, SH ;

Kim, HK .

MACROMOLECULAR RESEARCH, 2002, 10 (02) :103-107

[44] Fabrication of antibacterial silver nanoparticle-sodium alginate-chitosan composite films [J].

Sharma, Shilpa ;

Sanpui, Pallab ;

Chattopadhyay, Arun ;

Ghosh, Siddhartha Sankar .

RSC ADVANCES, 2012, 2 (13) :5837-5843

[45] STRUCTURE, FUNCTION, AND ASSEMBLY OF CELL-WALLS OF GRAM-POSITIVE BACTERIA [J].

SHOCKMAN, GD ;

BARRETT, JF .

ANNUAL REVIEW OF MICROBIOLOGY, 1983, 37 :501-527

[46]

Sibbald R Gary, 2007, Adv Skin Wound Care, V20, P549, DOI 10.1097/01.ASW.0000294757.05049.85

[47] Molecular modeling simulation and experimental measurements to characterize chitosan and poly(vinyl pyrrolidone) blend interactions [J].

Suknuntha, Krit ;

Tantishaiyakul, Vimon ;

Vao-Soongnern, Visit ;

Espidel, Youssef ;

Cosgrove, Terrence .

JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2008, 46 (12) :1258-1264

[48] Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs [J].

Ueno, H ;

Yamada, H ;

Tanaka, I ;

Kaba, N ;

Matsuura, M ;

Okumura, M ;

Kadosawa, T ;

Fujinaga, T .

BIOMATERIALS, 1999, 20 (15) :1407-1414

[49]

Vimala K., 2011, Journal of Biomaterials and Nanobiotechnology, V2, P55, DOI [DOI 10.4236/JBNB.2011.21008, 10.4236/jbnb.2011.21008]

[50] Chitosan/poly (vinyl pyrollidone) coatings improve the antibacterial properties of poly(ethylene terephthalate) [J].

Wang, Bai-liang ;

Wang, Jin-lei ;

Li, Dan-dan ;

Ren, Ke-feng ;

Ji, Jian .

APPLIED SURFACE SCIENCE, 2012, 258 (20) :7801-7808

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