Bio-nanotechnology and photodynamic therapy - State of the art review

被引：157

作者：

Allison, R. R. ^{[1
]}

Mota, H. C. ^{[1
]}

Bagnato, V. S. ^{[2
]}

Sibata, C. H. ^{[1
]}

机构：

[1] Brody Sch Med ECU, Greenville, NC 28758 USA

[2] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13566590 Sao Carlos, SP, Brazil

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2008年 / 5卷 / 01期

关键词：

photodynamic therapy; photodiagnosis; nanotechnology; review; nanoparticles;

D O I：

10.1016/j.pdpdt.2008.02.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Photodynamic therapy (PDT) and bio-nanotechnology (NT) show striking similarities in clinical design and mechanistics. The PDT paradigm of photosensitizer application, tight activation and singlet oxygen generation does in fact occur on the nanoscale level. as does the resultant outcomes. NT has the ability to explain as well as modify each of the critical steps of PDT particularly photosensitizer design and delivery, light source miniaturization and optimization, location and intensity of the photodynamic reaction as welt as offering a far greater insight into dosimetry and mechanisms of action. This review wilt explore the current and potential future interactions and modifications NT may have on PDT. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：19 / 28

页数：10

共 77 条

[1] Real-time detection of virus particles and viral protein expression with two-color nanoparticle probes
Agrawal, A
Tripp, RA
Anderson, LJ
Nie, SM
[J]. JOURNAL OF VIROLOGY, 2005, 79 (13) : 8625 - 8628
[2] Manufacture and use of nanomaterials: current status in the UK and global trends
Aitken, R. J.
Chaudhry, M. Q.
Boxall, A. B. A.
Hull, M.
[J]. OCCUPATIONAL MEDICINE-OXFORD, 2006, 56 (05): : 300 - 306
[3] PEG-COATED POLY(LACTIC ACID) NANOPARTICLES FOR THE DELIVERY OF HEXADECAFLUORO ZINC PHTHALOCYANINE TO EMT-6 MOUSE MAMMARY-TUMORS
ALLEMANN, E
BRASSEUR, N
BENREZZAK, O
ROUSSEAU, J
KUDREVICH, SV
BOYLE, RW
LEROUX, JC
GURNY, R
VANLIER, JE
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1995, 47 (05) : 382 - 387
[4] Allemann E, 1996, INT J CANCER, V66, P821, DOI 10.1002/(SICI)1097-0215(19960611)66:6<821::AID-IJC19>3.0.CO
[5] 2-5
[6] Clinical PD/PDT in North America: An historical review
Allison, R. R.
Mota, H. C.
Sibata, C. H.
[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2004, 1 (04) : 263 - 277
[7] Photosensitizers in clinical PDT
Allison, Ron R.
Downie, Gordon H.
Cuenca, Rosa
Hu, Xin-Hua
Childs, Carter J. H.
Sibata, Claudio H.
[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2004, 1 (01) : 27 - 42
[8] BAGNATO VS, 2007, PROGR REPORT CEPOF
[9] Detection of protein analytes via nanoparticle-based bio bar code technology
Bao, YP
Wei, TF
Lefebvre, PA
An, H
He, LX
Kunkel, GT
Müller, UR
[J]. ANALYTICAL CHEMISTRY, 2006, 78 (06) : 2055 - 2059
[10] Lysosomes and microtubules as targets for photochemotherapy of cancer
Berg, K
Moan, J
[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1997, 65 (03) : 403 - 409

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