Bio-nanotechnology and photodynamic therapy - State of the art review

被引：157

作者：

Allison, R. R. ^{[1
]}

Mota, H. C. ^{[1
]}

Bagnato, V. S. ^{[2
]}

Sibata, C. H. ^{[1
]}

机构：

[1] Brody Sch Med ECU, Greenville, NC 28758 USA

[2] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13566590 Sao Carlos, SP, Brazil

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2008年 / 5卷 / 01期

关键词：

photodynamic therapy; photodiagnosis; nanotechnology; review; nanoparticles;

D O I：

10.1016/j.pdpdt.2008.02.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Photodynamic therapy (PDT) and bio-nanotechnology (NT) show striking similarities in clinical design and mechanistics. The PDT paradigm of photosensitizer application, tight activation and singlet oxygen generation does in fact occur on the nanoscale level. as does the resultant outcomes. NT has the ability to explain as well as modify each of the critical steps of PDT particularly photosensitizer design and delivery, light source miniaturization and optimization, location and intensity of the photodynamic reaction as welt as offering a far greater insight into dosimetry and mechanisms of action. This review wilt explore the current and potential future interactions and modifications NT may have on PDT. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：19 / 28

页数：10

共 77 条

[41] Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy
Koo, Yong-Eun Lee
Fan, Wenzhe
Hah, Hoejin
Xu, Hao
Orringer, Dan
Ross, Brian
Rehemtulla, Alnawaz
Philbert, Martin A.
Kopelman, Raoul
[J]. APPLIED OPTICS, 2007, 46 (10) : 1924 - 1930
[42] A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks
Lam, CW
James, JT
McCluskey, R
Arepalli, S
Hunter, RL
[J]. CRITICAL REVIEWS IN TOXICOLOGY, 2006, 36 (03) : 189 - 217
[43] Aquatic colloids and nanoparticles: Current knowledge and future trends
Lead, Jamie R.
Wilkinson, Kevin J.
[J]. ENVIRONMENTAL CHEMISTRY, 2006, 3 (03) : 159 - 171
[44] LEE C, 2005, 5 IEEE C NAN
[45] Lasers and light sources for PDT: past, present and future
Mang, Thomas S.
[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2004, 1 (01) : 43 - 48
[46] MONSON E, 2003, BIOMEDICAL PHOTONICS, P59
[47] Moser J, 1998, 2 3 GENERATION PHOTO
[48] An introduction to nanotechnologies: What's in it for us?
Narducci, D.
[J]. VETERINARY RESEARCH COMMUNICATIONS, 2007, 31 (Suppl 1) : 131 - 137
[49] Toxic potential of materials at the nanolevel
Nel, A
Xia, T
Mädler, L
Li, N
[J]. SCIENCE, 2006, 311 (5761) : 622 - 627
[50] Occurrence, behavior and effects of nanoparticles in the environment
Nowack, Bernd
Bucheli, Thomas D.
[J]. ENVIRONMENTAL POLLUTION, 2007, 150 (01) : 5 - 22

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