Lysosomal cysteine proteases: Structure, function and inhibition of cathepsins

被引：45

作者：

Roberts, R

机构：

[1] Ursinus Coll, Dept Biol, Collegeville, PA 19426 USA

[2] Ursinus Coll, Program Biochem & Mol Biol, Collegeville, PA 19426 USA

来源：

DRUG NEWS & PERSPECTIVES | 2005年 / 18卷 / 10期

关键词：

D O I：

10.1358/dnp.2005.18.10.949485

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lysosomal cysteine proteases, a subgroup of the cathepsin family, are critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. In the past decade, the number of identified human cathepsins has more than doubled and their known role in several pathologies has expanded rapidly. Increased understanding of the structure and mechanism of this class of enzymes has brought on a new fervor in the design of small molecule inhibitors with the hope of producing specific, therapeutic drugs for diseases such as arthritis, allergy, multiple sclerosis, atherosclerosis, Alzheimer's disease and cancer. (c) 2005 Prous Science. Ail rights reserved.

引用

收藏

页码：605 / 614

页数：10

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