Ubiquitous expression of a Drosophila adenomatous polyposis coli homolog and its localization in cortical actin caps

被引：26

作者：

Yu, X ^{[1
]}

Bienz, M ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

MECHANISMS OF DEVELOPMENT | 1999年 / 84卷 / 1-2期

关键词：

adenomatous polyposis coil; cortical actin caps; blastoderm embryo; microtubules; Drosophila;

D O I：

10.1016/S0925-4773(99)00072-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report the expression pattern of a new adenomatous polyposis coli (APC) homolog called E-APC during Drosophila development. E-APC protein is expressed in all embryonic and larval cells we have examined. In the early blastoderm embryo, we see a striking concentration of E-APC in the cortical actin caps. Microtubules are closely associated with these caps. Since human APC has been reported to bind to microtubules, we investigated whether the cortical E-APC co-localizes with tubulin. However, this was not the case, implying that the putative tubulin-binding property of human APC is not well conserved. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：69 / 73

页数：5

共 22 条

[1] Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development [J].