Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways

被引：503

作者：

Barth, AI

Nathke, IS

Nelson, WJ

机构：

[1] Dept. of Molec. and Cell. Physiology, Beckman Ctr. Molec. and Genetic Med., Stanford Univ. School of Medicine, Stanford

来源：

CURRENT OPINION IN CELL BIOLOGY | 1997年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(97)80122-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Cadherins play important roles in cell-cell adhesion during tissue differentiation. Cadherins are linked to the actin cytoskeleton by catenins (beta-catenin/armadillo, plakoglobin, and alpha-catenin). Recent results show that beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis.

引用

页码：683 / 690

页数：8

共 95 条

[1]

Aberle H, 1996, J CELL BIOCHEM, V61, P514, DOI 10.1002/(SICI)1097-4644(19960616)61:4<514::AID-JCB4>3.0.CO

[2]

2-R

[3]

beta-catenin is a target for the ubiquitin-proteasome pathway [J].

Aberle, H ;

Bauer, A ;

Stappert, J ;

Kispert, A ;

Kemler, R .

EMBO JOURNAL, 1997, 16 (13) :3797-3804

[4]

Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion [J].

Adams, CL ;

Nelson, WJ ;

Smith, SJ .

JOURNAL OF CELL BIOLOGY, 1996, 135 (06) :1899-1911

[5]

THE INTERACTION OF THE RETINA CELL-SURFACE N-ACETYLGALACTOSAMINYLPHOSPHOTRANSFERASE WITH AN ENDOGENOUS PROTEOGLYCAN LIGAND RESULTS IN INHIBITION OF CADHERIN-MEDIATED ADHESION [J].

BALSAMO, J ;

ERNST, H ;

ZANIN, MKB ;

HOFFMAN, S ;

LILIEN, J .

JOURNAL OF CELL BIOLOGY, 1995, 129 (05) :1391-1401

[6]

Regulated binding of a PTP1B-like phosphatase to N-cadherin: Control of cadherin-mediated adhesion by dephosphorylation of beta-catenin [J].

Balsamo, J ;

Leung, TC ;

Ernst, H ;

Zanin, MKB ;

Hoffman, S ;

Lilien, J .

JOURNAL OF CELL BIOLOGY, 1996, 134 (03) :801-813

[7]

NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion [J].

Barth, AIM ;

Pollack, AL ;

Altschuler, Y ;

Mostov, KE ;

Nelson, WJ .

JOURNAL OF CELL BIOLOGY, 1997, 136 (03) :693-706

[8]

Functional interaction of beta-catenin with the transcription factor LEF-1 [J].

Behrens, J ;

vonKries, JP ;

Kuhl, M ;

Bruhn, L ;

Wedlich, D ;

Grosschedl, R ;

Birchmeier, W .

NATURE, 1996, 382 (6592) :638-642

[9]

LOSS OF EPITHELIAL DIFFERENTIATION AND GAIN OF INVASIVENESS CORRELATES WITH TYROSINE PHOSPHORYLATION OF THE E-CADHERIN BETA-CATENIN COMPLEX IN CELLS TRANSFORMED WITH A TEMPERATURE-SENSITIVE V-SRC GENE [J].

BEHRENS, J ;

VAKAET, L ;

FRIIS, R ;

WINTERHAGER, E ;

VANROY, F ;

MAREEL, MM ;

BIRCHMEIER, W .

JOURNAL OF CELL BIOLOGY, 1993, 120 (03) :757-766

[10]

A new member of the frizzled family from Drosophila functions as a Wingless receptor [J].

Bhanot, P ;

Brink, M ;

Samos, CH ;

Hsieh, JC ;

Wang, YS ;

Macke, JP ;

Andrew, D ;

Nathans, J ;

Nusse, R .

NATURE, 1996, 382 (6588) :225-230

← 1 2 3 4 5 6 7 8 9 10 →