Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling

被引：177

作者：

Smith, JT

Clifton, DK

Steiner, RA

机构：

[1] Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA

[2] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA

来源：

REPRODUCTION | 2006年 / 131卷 / 04期

关键词：

D O I：

10.1530/rep.1.00368

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Kiss1 gene codes for a family of peptides that act as endogenous ligands for the G protein-coupled receptor GPR54. Spontaneous mutations or targeted deletions of GPR54 in man and mice produce hypogonadotropic hypogonadism and infertility. Centrally administered kisspeptins stimulate gonadotropin secretion by acting directly on GnRH neurons. Sex steroids regulate the expression of KiSS-1 mRNA in the brain through direct action on KiSS-1 neurons. In the arcuate nucleus (Arc), sex steroids inhibit the expression of KiSS-1, suggesting that these neurons serve as a conduit for the negative feedback regulation of gonadotropin secretion. In the anteroventral periventricular nucleus (AVPV), sex steroids induce the expression of KiSS-1, implying that KiSS-1 neurons in this region may have a role in the preovulatory LH surge (in the female) or sexual behavior (in the male).

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页码：623 / 630

页数：8

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