Ambient mass spectrometry

被引:1215
作者
Cooks, RG [1 ]
Ouyang, Z
Takats, Z
Wiseman, JM
机构
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
[2] Hungarian Acad Sci, Chem Res Ctr, Inst Struct Chem, Budapest, Hungary
关键词
D O I
10.1126/science.1119426
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A recent innovation in mass spectrometry is the ability to record mass spectra on ordinary samples, in their native environment, without sample preparation or preseparation by creating ions outside the instrument. In desorption electrospray ionization (DESI), the principal method described here, electrically charged droplets are directed at the ambient object of interest; they release ions from the surface, which are then vacuumed through the air into a conventional mass spectrometer. Extremely rapid analysis is coupled with high sensitivity and high chemical specificity. These characteristics are advantageously applied to high-throughput metabolomics, explosives detection, natural products discovery, and biological tissue imaging, among other applications. Future possible uses of DESI for in vivo clinical analysis and its adaptation to portable mass spectrometers are described.
引用
收藏
页码:1566 / 1570
页数:5
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