Aluminum as a toxicant

被引：225

作者：

Becaria, A ^{[1
]}

Campbell, A ^{[1
]}

Bondy, SC ^{[1
]}

机构：

[1] Ctr Occupat & Environm Hlth Sci, Dept Community & Environm Med, Fac Res Facil, Irvine, CA 92697 USA

来源：

TOXICOLOGY AND INDUSTRIAL HEALTH | 2002年 / 18卷 / 07期

关键词：

inflammation; metal; neurodegenerative disease; neurotoxicology; oxidative stress;

D O I：

10.1191/0748233702th157oa

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Although aluminum is the most abundant metal in nature, it has no known biological function. However, it is known that there is a causal role for aluminum in dialysis encephalopathy, microcytic anemia, and osteomalacia. Aluminum has also been proposed to play a role in the pathogenesis of Alzheimer's disease (AD) even though this issue is controversial. The exact mechanism of aluminum toxicity is not known but accumulating evidence suggests that the metal can potentiate oxidative and inflammatory events, eventually leading to tissue damage. This review encompasses the general toxicology of aluminum with emphasis on the potential mechanisms by which it may accelerate the progression of chronic age-related neurodegenerative disorders.

引用

页码：309 / 320

页数：12