Global high-throughput screens for cellular function

被引：12

作者：

Hauptschein, RS ^{[1
]}

Eustace, BK ^{[1
]}

Jay, DG ^{[1
]}

机构：

[1] Tufts Univ, Sch Med, Dept Physiol, Boston, MA 02111 USA

来源：

EXPERIMENTAL HEMATOLOGY | 2002年 / 30卷 / 05期

关键词：

D O I：

10.1016/S0301-472X(02)00783-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is a critical need for global methods that allow for high-throughput assessment of cellular function for clinical and basic scientists working in both academia and the pharmaceutical industry. These methods typically couple systematic inactivation strategies with high-throughput cell-based assays that facilitate rapid target validation. We present here a survey of these technologies and their applications. We discuss their promise and limitations in addressing the vast number of candidate molecules of disease relevance that are emerging from genomics and proteomics. (C) 2002 International Society for Experimental Hematology. Published by Elsevier Science Inc.

引用

页码：381 / 387

页数：7

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