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Parkinson's - Divergent causes, convergent mechanisms
被引:347
作者
:
Greenamyre, JT
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
Greenamyre, JT
[
1
]
Hastings, TG
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
Hastings, TG
机构
:
[1]
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
[2]
Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA
来源
:
SCIENCE
|
2004年
/ 304卷
/ 5674期
关键词
:
D O I
:
10.1126/science.1098966
中图分类号
:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号
:
07 ;
0710 ;
09 ;
摘要
:
[No abstract available]
引用
收藏
页码:1120 / 1122
页数:3
相关论文
共 21 条
[1]
Commentary on "Alpha-synuclein and mitochondria: a tangled skein"
Beal, MF
论文数:
0
引用数:
0
h-index:
0
机构:
Cornell Univ, Weill Med Coll, New York, NY 10021 USA
Cornell Univ, Weill Med Coll, New York, NY 10021 USA
Beal, MF
[J].
EXPERIMENTAL NEUROLOGY,
2004,
186
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111
[2]
Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: Implications for Parkinson's disease
Berman, SB
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15261 USA
Berman, SB
Hastings, TG
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15261 USA
Hastings, TG
[J].
JOURNAL OF NEUROCHEMISTRY,
1999,
73
(03)
: 1127
-
1137
[3]
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Betarbet, R
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Betarbet, R
Sherer, TB
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Sherer, TB
MacKenzie, G
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
MacKenzie, G
Garcia-Osuna, M
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Garcia-Osuna, M
Panov, AV
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Panov, AV
Greenamyre, JT
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Greenamyre, JT
[J].
NATURE NEUROSCIENCE,
2000,
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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
Bonifati, V
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Bonifati, V
Rizzu, P
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Rizzu, P
van Baren, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Baren, MJ
Schaap, O
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Schaap, O
Breedveld, GJ
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Breedveld, GJ
Krieger, E
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Krieger, E
Dekker, MCJ
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Dekker, MCJ
Squitieri, F
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Squitieri, F
Ibanez, P
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Ibanez, P
Joosse, M
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Joosse, M
van Dongen, JW
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Dongen, JW
Vanacore, N
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Vanacore, N
van Swieten, JC
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Swieten, JC
Brice, A
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Brice, A
Meco, G
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Meco, G
van Duijn, CM
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Duijn, CM
Oostra, BA
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Oostra, BA
Heutink, P
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Heutink, P
[J].
SCIENCE,
2003,
299
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: 256
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259
[5]
CHEN R, 2004, J BIOL CHEM
[6]
Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
Conway, KA
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Conway, KA
Rochet, JC
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Rochet, JC
Bieganski, RM
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Bieganski, RM
Lansbury, PT
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Lansbury, PT
[J].
SCIENCE,
2001,
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Molecular pathways of neurodegeneration in Parkinson's disease
Dawson, TM
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0
引用数:
0
h-index:
0
机构:
Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
Dawson, TM
Dawson, VL
论文数:
0
引用数:
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h-index:
0
机构:
Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
Dawson, VL
[J].
SCIENCE,
2003,
302
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: 819
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822
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Oxidative stress in Parkinson's disease
Jenner, P
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0
引用数:
0
h-index:
0
机构:
Kings Coll London, GKT Sch Biomed Sci, NDRC, London SE1 1UL, England
Kings Coll London, GKT Sch Biomed Sci, NDRC, London SE1 1UL, England
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Kitada, T
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机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Kitada, T
Asakawa, S
论文数:
0
引用数:
0
h-index:
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机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Asakawa, S
Hattori, N
论文数:
0
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h-index:
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机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Hattori, N
Matsumine, H
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0
引用数:
0
h-index:
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机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Matsumine, H
Yamamura, Y
论文数:
0
引用数:
0
h-index:
0
机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Yamamura, Y
Minoshima, S
论文数:
0
引用数:
0
h-index:
0
机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Minoshima, S
Yokochi, M
论文数:
0
引用数:
0
h-index:
0
机构:
Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
Yokochi, M
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引用数:
h-index:
机构:
Mizuno, Y
Shimizu, N
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Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo 1608582, Japan
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CHRONIC PARKINSONISM IN HUMANS DUE TO A PRODUCT OF MEPERIDINE-ANALOG SYNTHESIS
LANGSTON, JW
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SANTA CLARA VALLEY MED CTR,SAN JOSE,CA 95128
LANGSTON, JW
论文数:
引用数:
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BALLARD, P
TETRUD, JW
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0
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0
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0
机构:
SANTA CLARA VALLEY MED CTR,SAN JOSE,CA 95128
TETRUD, JW
IRWIN, I
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SANTA CLARA VALLEY MED CTR,SAN JOSE,CA 95128
IRWIN, I
[J].
SCIENCE,
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←
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2
3
→
共 21 条
[1]
Commentary on "Alpha-synuclein and mitochondria: a tangled skein"
Beal, MF
论文数:
0
引用数:
0
h-index:
0
机构:
Cornell Univ, Weill Med Coll, New York, NY 10021 USA
Cornell Univ, Weill Med Coll, New York, NY 10021 USA
Beal, MF
[J].
EXPERIMENTAL NEUROLOGY,
2004,
186
(02)
: 109
-
111
[2]
Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: Implications for Parkinson's disease
Berman, SB
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15261 USA
Berman, SB
Hastings, TG
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15261 USA
Hastings, TG
[J].
JOURNAL OF NEUROCHEMISTRY,
1999,
73
(03)
: 1127
-
1137
[3]
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Betarbet, R
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Betarbet, R
Sherer, TB
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Sherer, TB
MacKenzie, G
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
MacKenzie, G
Garcia-Osuna, M
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Garcia-Osuna, M
Panov, AV
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Panov, AV
Greenamyre, JT
论文数:
0
引用数:
0
h-index:
0
机构:
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
Greenamyre, JT
[J].
NATURE NEUROSCIENCE,
2000,
3
(12)
: 1301
-
1306
[4]
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
Bonifati, V
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Bonifati, V
Rizzu, P
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Rizzu, P
van Baren, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Baren, MJ
Schaap, O
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Schaap, O
Breedveld, GJ
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Breedveld, GJ
Krieger, E
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Krieger, E
Dekker, MCJ
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Dekker, MCJ
Squitieri, F
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Squitieri, F
Ibanez, P
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Ibanez, P
Joosse, M
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Joosse, M
van Dongen, JW
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Dongen, JW
Vanacore, N
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Vanacore, N
van Swieten, JC
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Swieten, JC
Brice, A
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Brice, A
Meco, G
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Meco, G
van Duijn, CM
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
van Duijn, CM
Oostra, BA
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Oostra, BA
Heutink, P
论文数:
0
引用数:
0
h-index:
0
机构:
Erasmus MC, Dept Epidemiol & Biostat, Dept Clin Genet, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands
Heutink, P
[J].
SCIENCE,
2003,
299
(5604)
: 256
-
259
[5]
CHEN R, 2004, J BIOL CHEM
[6]
Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
Conway, KA
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Conway, KA
Rochet, JC
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Rochet, JC
Bieganski, RM
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Bieganski, RM
Lansbury, PT
论文数:
0
引用数:
0
h-index:
0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Lansbury, PT
[J].
SCIENCE,
2001,
294
(5545)
: 1346
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1349
[7]
Molecular pathways of neurodegeneration in Parkinson's disease
Dawson, TM
论文数:
0
引用数:
0
h-index:
0
机构:
Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
Dawson, TM
Dawson, VL
论文数:
0
引用数:
0
h-index:
0
机构:
Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
Dawson, VL
[J].
SCIENCE,
2003,
302
(5646)
: 819
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822
[8]
Oxidative stress in Parkinson's disease
Jenner, P
论文数:
0
引用数:
0
h-index:
0
机构:
Kings Coll London, GKT Sch Biomed Sci, NDRC, London SE1 1UL, England
Kings Coll London, GKT Sch Biomed Sci, NDRC, London SE1 1UL, England
Jenner, P
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