The hydroxylation of testosterone and some relatives by Cephalosporium aphidicola

被引：50

作者：

Hanson, JR

Nasir, H

Parvez, A

机构：

[1] School of Molecular Sciences, University of Sussex

来源：

PHYTOCHEMISTRY | 1996年 / 42卷 / 02期

关键词：

Cephalosporium aphidicola; microbiological hydroxylation; steroid; testosterone;

D O I：

10.1016/0031-9422(95)00968-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fungus Cephalosporium aphidicola has been shown to hydroxylate testosterone, 19-nortestosterone, 1-dehydrotestosterone, 1 alpha-methyltestosterone, androst-4-en-3-one, androst-4-en-3,17-dione and 17 alpha-methyltestosterone predominantly at the C-6 beta position with a minor hydroxylation occurring at the C-14 alpha position. 19-Nortestosterone was also hydroxylated at the C-10 beta position. In contrast to the hydroxylation of progesterone by this organism, hydroxylation at C-11 alpha was a minor pathway.

引用

页码：411 / 415

页数：5

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