Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: A review

被引:162
作者
Chen, Fei [1 ]
Hu, Shen-Jiang [1 ]
机构
[1] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Cardiol, Hangzhou 310003, Zhejiang, Peoples R China
关键词
miR-34a; Cell Cycle; Differentiation; Apoptosis; ONCOGENE-INDUCED SENESCENCE; P53; TUMOR-SUPPRESSOR; IDENTIFIES MIR-34A; DOWN-REGULATION; CANCER; EXPRESSION; NEUROBLASTOMA; ACTIVATION; REGULATOR; PROLIFERATION;
D O I
10.1002/jbt.20412
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The tumor suppressor gene p53 was shown to directly regulate the expression of microRNA-34a (miR-34a). miR-34a regulates a plethora of target proteins, which are involved in cell cycle, apoptosis, differentiation, and cellular development.miR-34a resides in the region of chromosome 1p36.23, which is commonly deleted in many tumor types, while it results in the loss expression of miR-34a. The promoters of the miR-34a gene subject to inactivation by CpG methylation also induce the loss expression of miR-34a. Ectopic miR-34a expression induces apoptosis, cell cycle arrest, and differentiation or reduces migration. This review summarizes the progress regarding the role of miR-34a in cell cycle, differentiation, and apoptosis. (c) 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:7986 2012; View this article online at . DOI 10.1002/jbt.20412
引用
收藏
页码:79 / 86
页数:8
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