Recovering quasi-active properties of dendritic neurons from dual potential recordings

被引：16

作者：

Cox, SJ ^{[1
]}

Griffith, BE ^{[1
]}

机构：

[1] Rice Univ, Dept Computat & Appl Math, Houston, TX 77005 USA

来源：

JOURNAL OF COMPUTATIONAL NEUROSCIENCE | 2001年 / 11卷 / 02期

基金：

美国国家科学基金会;

关键词：

identification; parameter estimation; moment methods; symbolic solution; Laplace transform;

D O I：

10.1023/A:1012858230117

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We develop the theory and accompanying algorithm for the recovery of a dendritic neuron's cytoplasmic resistivity, membrane capacitance, leakage conductance, and two maximal channel conductances from weighted averages of simultaneous recordings of somatic and dendritic potential following a somatic current stimulus. We test our results on two model systems with distinct, though prescribed, channel kinetics and branching patterns.

引用

页码：95 / 110

页数：16

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