Dependence of Mos-induced Cdc2 activation on MAP kinase function in a cell-free system

被引:55
作者
Huang, CYF [1 ]
Ferrell, JE [1 ]
机构
[1] STANFORD UNIV,DEPT MOLEC PHARMACOL,SCH MED,STANFORD,CA 94305
关键词
Cdc2; MAP kinase; Mos; Xenopus laevis;
D O I
10.1002/j.1460-2075.1996.tb00570.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The progression of G(2)-arrested Xenopus laevis oocytes into meiotic M-phase is accompanied by the nearly simultaneous activation of p42 MAP kinase and Cdc2/cyclin B, This timing raises the possibility that the activation of one kinase might depend upon the other, Here we have examined whether Cdc2 activation requires p42 MAP kinase function. We have reconstituted Mos-induced Cdc2 activation in cell-free Xenopus oocyte extracts, and have found that Mos-induced Cdc2 activation requires active p42 MAP kinase, is inhibited by a MAP kinase phosphatase and is independent of protein synthesis. These findings indicate that p42 MAP kinase is an essential component of the M phase trigger in this system.
引用
收藏
页码:2169 / 2173
页数:5
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