Tandem Palladium-Catalyzed N,C-Coupling/Carbonylation Sequence for the Synthesis of 2-Carboxyindoles

被引：96

作者：

Vieira, Tiago O. ^{[1
]}

Meaney, Laura A. ^{[1
]}

Shi, Yong-Ling ^{[1
]}

Alper, Howard ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 21期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1021/ol801985q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tandem palladium-catalyzed N,C-coupling/carbonylation, under 10 atm of carbon monoxide and at 110 degrees C, is a novel and efficient method for the preparation of 2-carboxyindoles. The catalyst system tolerates a variety of functional groups, and the noted indoles were obtained in good isolated yields.

引用

页码：4899 / 4901

页数：3

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