Proteases and the biology of glioma invasion

被引：43

作者：

Binder, DK ^{[1
]}

Berger, MS ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 2002年 / 56卷 / 02期

关键词：

matrix metalloproteases; invasion; gliomas; extracellular matrix; growth factors; tumor suppressor genes;

D O I：

10.1023/A:1014566604005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite optimal clinical treatment, the prognosis for malignant gliomas remains poor. One of the primary reasons for treatment failure is not diffuse dissemination, but local invasion. Recently, there has been an increase in information regarding specific molecules that determine the aggressiveness and invasion potential of high-grade astrocytic tumors. In particular, expression of matrix metalloproteases in high-grade gliomas appears to correlate with tissue invasiveness. It is the purpose of the present review to describe the connection between alterations in growth-related genes, protease activity, and tumor biology, and how these connections may suggest potential novel therapeutic targets.

引用

页码：149 / 158

页数：10

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