THE MOLECULAR-BIOLOGY OF BRAIN-TUMORS

被引：11

作者：

BARKER, FG

ISRAEL, MA

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,BRAIN TUMOR RES CTR,PREUSS LAB MOLEC NEUROONCOL,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,SCH MED,BRAIN TUMOR RES CTR,PREUSS LAB MOLEC NEUROONCOL,DEPT PEDIAT,SAN FRANCISCO,CA 94143

来源：

NEUROLOGIC CLINICS | 1995年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0733-8619(18)30014-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cancer currently is thought to arise in association with the accumulation of specific structural genetic alterations within somatic cells. This article reviews the molecular genetic alterations associated with human brain tumors, including mutation or deletion of tumor suppressor genes (P53, NF1, NF2, RB1, CDKN2, APC, and the Gorlin and MEN1 loci) and activation of proto-oncogenes (EFGR, other growth factors and receptors, ras and mile families, res, gli, gsp). Molecular genetic changes associated with astrocytic tumors, oligodendrogliomas, ependymomas, medulloblastomas, meningiomas, schwannomas, and pituitary adenomas are discussed.

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页码：701 / &

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