THE MOLECULAR-BIOLOGY OF BRAIN-TUMORS

被引：11

作者：

BARKER, FG

ISRAEL, MA

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,BRAIN TUMOR RES CTR,PREUSS LAB MOLEC NEUROONCOL,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,SCH MED,BRAIN TUMOR RES CTR,PREUSS LAB MOLEC NEUROONCOL,DEPT PEDIAT,SAN FRANCISCO,CA 94143

来源：

NEUROLOGIC CLINICS | 1995年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0733-8619(18)30014-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cancer currently is thought to arise in association with the accumulation of specific structural genetic alterations within somatic cells. This article reviews the molecular genetic alterations associated with human brain tumors, including mutation or deletion of tumor suppressor genes (P53, NF1, NF2, RB1, CDKN2, APC, and the Gorlin and MEN1 loci) and activation of proto-oncogenes (EFGR, other growth factors and receptors, ras and mile families, res, gli, gsp). Molecular genetic changes associated with astrocytic tumors, oligodendrogliomas, ependymomas, medulloblastomas, meningiomas, schwannomas, and pituitary adenomas are discussed.

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页码：701 / &

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共 171 条

[91]

MASHIYAMA S, 1991, ONCOGENE, V6, P1313

[92] THE TRANSFORMING GROWTH-FACTOR-BETA FAMILY [J].

MASSAGUE, J .

ANNUAL REVIEW OF CELL BIOLOGY, 1990, 6 :597-641

[93] EFFECT OF THE EXPRESSION OF TRANSFORMING GROWTH-FACTOR-BETA-2 IN PRIMARY HUMAN GLIOBLASTOMAS ON IMMUNOSUPPRESSION AND LOSS OF IMMUNE SURVEILLANCE [J].

MAXWELL, M ;

GALANOPOULOS, T ;

NEVILLEGOLDEN, J ;

ANTONIADES, HN .

JOURNAL OF NEUROSURGERY, 1992, 76 (05) :799-804

[94] COEXPRESSION OF PLATELET-DERIVED GROWTH-FACTOR (PDGF) AND PDGF-RECEPTOR GENES BY PRIMARY HUMAN ASTROCYTOMAS MAY CONTRIBUTE TO THEIR DEVELOPMENT AND MAINTENANCE [J].

MAXWELL, M ;

NABER, SP ;

WOLFE, HJ ;

GALANOPOULOS, T ;

HEDLEYWHYTE, ET ;

BLACK, PM ;

ANTONIADES, HN .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (01) :131-140

[95] PHYSICAL MAPPING OF CHROMOSOME 17P13.3 IN THE REGION OF A PUTATIVE TUMOR-SUPPRESSOR GENE IMPORTANT IN MEDULLOBLASTOMA [J].

MCDONALD, JD ;

DANESHVAR, L ;

WILLERT, JR ;

MATSUMURA, K ;

WALDMAN, F ;

COGEN, PH .

GENOMICS, 1994, 23 (01) :229-232

[96] CONTROL OF HUMAN GLIOMA CELL-GROWTH, MIGRATION AND INVASION IN-VITRO BY TRANSFORMING GROWTH-FACTOR BETA(1) [J].

MERZAK, A ;

MCCREA, S ;

KOOCHECKPOUR, S ;

PILKINGTON, GJ .

BRITISH JOURNAL OF CANCER, 1994, 70 (02) :199-203

[97] IDENTIFICATION OF A GERM-LINE MUTATION IN THE P53 GENE IN A PATIENT WITH AN INTRACRANIAL EPENDYMOMA [J].

METZGER, AK ;

SHEFFIELD, VC ;

DUYK, G ;

DANESHVAR, L ;

EDWARDS, MSB ;

COGEN, PH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7825-7829

[98]

MIZUNO M, 1990, CANCER RES, V50, P7826

[99] GERM-LINE AND SOMATIC MUTATIONS ED THE APC GENE IN PATIENTS WITH TURCOT SYNDROME AND ANALYSIS OF APC MUTATIONS IN BRAIN-TUMORS [J].

MORI, T ;

NAGASE, H ;

HORII, A ;

MIYOSHI, Y ;

SHIMANO, T ;

NAKATSURU, S ;

AOKI, T ;

ARAKAWA, H ;

YANAGISAWA, A ;

USHIO, Y ;

TAKANO, S ;

OGAWA, M ;

NAKAMURA, M ;

SHIBUYA, M ;

NISHIKAWA, R ;

MATSUTANI, M ;

HAYASHI, Y ;

TAKAHASHI, H ;

IKUTA, F ;

NISHIHIRA, T ;

MORI, S ;

NAKAMURA, Y .

GENES CHROMOSOMES & CANCER, 1994, 9 (03) :168-172

[100] BASIC FIBROBLAST GROWTH-FACTOR AND FIBROBLAST GROWTH-FACTOR RECEPTOR-I ARE IMPLICATED IN THE GROWTH OF HUMAN ASTROCYTOMAS [J].

MORRISON, RS ;

YAMAGUCHI, F ;

SAYA, H ;

BRUNER, JM ;

YAHANDA, AM ;

DONEHOWER, LA ;

BERGER, M .

JOURNAL OF NEURO-ONCOLOGY, 1994, 18 (03) :207-216

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