Mild nitrosation and hydrolysis of polyfunctional amides

被引：66

作者：

Evans, DA

Carter, PH

Dinsmore, CJ

Barrow, JC

Katz, JL

Kung, DW

机构：

[1] Dept. of Chem. and Chemical Biology, Harvard University, Cambridge

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(97)00972-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Secondary amides may be hydrolyzed via a mild, high-yielding sequence consisting of N-nitrosation, treatment with lithium hydroperoxide, and reduction with sodium sulfite. These operations may be executed in the presence of an array of functional groups, including other amide functionality. (C) 1997 Elsevier Science Ltd.

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页码：4535 / 4538

页数：4

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