Picking the S1, S1′ and S2′ pockets of matrix metalloproteinases.: A niche for potent acyclic sulfonamide inhibitors

被引:39
作者
Hanessian, S [1 ]
Bouzbouz, S [1 ]
Boudon, A [1 ]
Tucker, GC [1 ]
Peyroulan, D [1 ]
机构
[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada
关键词
D O I
10.1016/S0960-894X(99)00259-0
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of acyclic hydroxamic acids harboring strategically placed alpha-arylsulfonamido and thioether groups was synthesized and found to be potent inhibitors of various MMPs. An unprecedented cleavage of t-butyl hydroxamates to hydroxamic acids was found. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1691 / 1696
页数:6
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