Picking the S1, S1′ and S2′ pockets of matrix metalloproteinases.: A niche for potent acyclic sulfonamide inhibitors

被引：39

作者：

Hanessian, S ^{[1
]}

Bouzbouz, S ^{[1
]}

Boudon, A ^{[1
]}

Tucker, GC ^{[1
]}

Peyroulan, D ^{[1
]}

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(99)00259-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of acyclic hydroxamic acids harboring strategically placed alpha-arylsulfonamido and thioether groups was synthesized and found to be potent inhibitors of various MMPs. An unprecedented cleavage of t-butyl hydroxamates to hydroxamic acids was found. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1691 / 1696

页数：6

共 34 条

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