Three Dyslexia Susceptibility Genes, DYX1C1, DCDC2, and KIAA0319, Affect Temporo-Parietal White Matter Structure

被引：116

作者：

Darki, Fahimeh ^{[1
]}

Peyrard-Janvid, Myriam ^{[2
]}

Matsson, Hans ^{[2
]}

Kere, Juha ^{[2
,3
,4
]}

Klingberg, Torkel ^{[1
]}

机构：

[1] Karolinska Inst, Dept Neurosci, S-17176 Stockholm, Sweden

[2] Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden

[3] Karolinska Inst, Sci Life Lab, Solna, Sweden

[4] Univ Helsinki, Haartman Inst, Res Programs Unit, Helsinki, Finland

来源：

BIOLOGICAL PSYCHIATRY | 2012年 / 72卷 / 08期

基金：

瑞典研究理事会;

关键词：

Diffusion tensor imaging; dyslexia genes; general population; reading ability; single nucleotide polymorphism; SNP; DEVELOPMENTAL DYSLEXIA; NEURONAL MIGRATION; READING-DISABILITY; WORKING-MEMORY; CANDIDATE GENE; DISRUPTION; MICROSTRUCTURE; ASSOCIATION; ACTIVATION; EXPRESSION;

D O I：

10.1016/j.biopsych.2012.05.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Volume and integrity of white matter correlate with reading ability, but the underlying factors contributing to this variability are unknown. Methods: We investigated single nucleotide polymorphisms in three genes previously associated with dyslexia and implicated in neuronal migration (DYX1C1, DCDC2, KIAA0319) and white matter volume in a cohort of 76 children and young adults from the general population. Results: We found that all three genes contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability. Conclusions: The identified region contained white matter pathways connecting the middle temporal gyrus with the inferior parietal lobe. The finding links previous neuroimaging and genetic results and proposes a mechanism underlying variability in reading ability in both normal and impaired readers.

引用

页码：671 / 676

页数：6

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