Osteoblast-derived microvesicles: A novel mechanism for communication between osteoblasts and osteoclasts

被引：163

作者：

Deng, Lili ^{[1
]}

Wang, Yaping ^{[2
]}

Peng, Ying ^{[1
]}

Wu, Yu ^{[1
]}

Ding, Yuedi ^{[1
]}

Jiang, Yuhai ^{[2
]}

Shen, Zhenhai ^{[3
]}

Fu, Qiang ^{[1
]}

机构：

[1] Jiangsu Inst Nucl Med, Jiangsu Key Lab Mol Nucl Med, Key Lab Nucl Med, Minist Hlth, Wuxi 214063, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Wuxi Peoples Hosp 2, Wuxi, Jiangsu, Peoples R China

[3] Jiangsu Prov Taihu Rehabil Hosp, Wuxi, Jiangsu, Peoples R China

来源：

BONE | 2015年 / 79卷

基金：

中国国家自然科学基金;

关键词：

Microvesicles; Cellular communication; Osteoblast; Osteoclast; RANKL-RANK pathway; MESSENGER-RNA; MICROPARTICLES; MEDIATORS;

D O I：

10.1016/j.bone.2015.05.022

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The maintenance of bone homeostasis is largely dependent upon cellular communication between osteoclasts and osteoblasts. Microvesicles (MVs) have received a good deal of attention and are increasingly considered as mediators of intercellular communication due to their capacity to merge with and transfer a repertoire of bioactive molecular content (cargo) to recipient cells, triggering a variety of biologic responses. Here, we demonstrated that MVs shed from osteoblasts contain RANKL protein and can transfer it to osteoclast precursors through receptor ligand (RANKL-RANK), leading to stimulation of RANKL-RANK signaling to facilitate osteoclast formation. Such MV-mediated intercellular communication between osteoblasts and osteoclasts may represent a novel mechanism of bone modeling and remodeling. It may be worthwhile to further explore MVs as tools to modify the biological responses of bone cells or develop an alternative drug to treat bone diseases. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：37 / 42

页数：6

共 21 条

[1]

Microvesicles Messengers and mediators of tumor progression [J].