Factors that regulate naturally occurring T regulatory cell-mediated suppression

被引：29

作者：

Goleva, E

Cardona, ID

Ou, LS

Leung, DYM

机构：

[1] Natl Jewish Med & Res Ctr, Dept Pediat, Denver, CO 80206 USA

[2] Chang Gung Childrens Hosp, Dept Pediat, Taoyuan, Taiwan

[3] Univ Colorado, Hlth Sci Ctr, Dept Pediat, Denver, CO 80262 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2005年 / 116卷 / 05期

关键词：

T regulatory cells; immune suppression; superantigens; atopic dermatitis;

D O I：

10.1016/j.jaci.2005.08.051

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

T regulatory (Treg) cells play a key role in the modulation of allergic and autoimmune responses. This review will discuss the factors that regulate naturally occurring Treg (nTreg) cell-mediated suppression. The involvement of cytokines, costimulatory molecules, and ligands; on antigen-presenting cells in the inhibition of nTreg cell-mediated suppression in vitro is summarized. Understanding the events that control suppressive function of nTreg cells will allow manipulation of these cells to inhibit or enhance their functions in the development of novel therapies for autoimmune and allergic diseases.

引用

收藏

页码：1094 / 1100

页数：7

相关论文

共 77 条

[1] T regulatory cells in allergy: Novel concepts in the pathogenesis, prevention, and treatment of allergic diseases [J].

Akdis, M ;

Blaser, K ;

Akdis, CA .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (05) :961-968

[2] Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis [J].

Balandina, A ;

Lécart, S ;

Dartevelle, P ;

Saoudi, A ;

Berrih-Aknin, S .

BLOOD, 2005, 105 (02) :735-741

[3] The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 [J].

Bennett, CL ;

Christie, J ;

Ramsdell, F ;

Brunkow, ME ;

Ferguson, PJ ;

Whitesell, L ;

Kelly, TE ;

Saulsbury, FT ;

Chance, PF ;

Ochs, HD .

NATURE GENETICS, 2001, 27 (01) :20-21

[4] Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells [J].

Bensinger, SJ ;

Walsh, PT ;

Zhang, JD ;

Carroll, M ;

Parsons, R ;

Rathmell, JC ;

Thompson, CB ;

Burchill, MA ;

Farrar, MA ;

Turka, LA .

JOURNAL OF IMMUNOLOGY, 2004, 172 (09) :5287-5296

[5] Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells [J].

Bettelli, E ;

Dastrange, M ;

Oukka, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (14) :5138-5143

[6] Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse [J].

Brunkow, ME ;

Jeffery, EW ;

Hjerrild, KA ;

Paeper, B ;

Clark, LB ;

Yasayko, SA ;

Wilkinson, JE ;

Galas, D ;

Ziegler, SF ;

Ramsdell, F .

NATURE GENETICS, 2001, 27 (01) :68-73

[7] Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide [J].

Caramalho, I ;

Lopes-Carvalho, T ;

Ostler, D ;

Zelenay, S ;

Haury, M ;

Demengeot, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (04) :403-411

[8]

CARDONA ID, 2005, J ALLERGY CLIN IMM S, V115, pS271

[9] Role of regulatory T cells in human diseases [J].

Chatila, TA .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (05) :949-959

[10] JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome [J].

Chatila, TA ;

Blaeser, F ;

Ho, N ;

Lederman, HM ;

Voulgaropoulos, C ;

Helms, C ;

Bowcock, AM .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (12) :R75-R81

← 1 2 3 4 5 6 7 8 →