Pyrrolo[1,2-f]phenanthridines and related non-rigid analogues as antiviral agents

被引：40

作者：

Almerico, AM

Mingoia, F

Diana, P

Barraja, P

Montalbano, A

Lauria, A

Loddo, R

Sanna, L

Delpiano, D

Setzu, MG

Musiu, C

机构：

[1] Univ Palermo, Dipartimento Farmacochim Tossicol & Biol, I-90123 Palermo, Italy

[2] CNR, Ist Chim & Tecnol Prodotti Nat, I-90146 Palermo, Italy

[3] Univ Cagliari, Dipartimento Biol Sperimentale, Sez Microbiol, I-09042 Cagliari, Italy

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 37卷 / 01期

关键词：

pyrrolo[1,2-f]phenanthridines (PPHs); non-rigid analogues; anti-HIV activity;

D O I：

10.1016/S0223-5234(01)01289-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The pyrrolo[1,2-f]phenanthridines 8-22 and the corresponding non-rigid analogues 23-41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10, 11, and 13 showed a weak anti-HIV activity, whereas several pyrrolo-phenanthridines (8, 10, 16-18) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：3 / 10

页数：8

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