Applications of nanotechnology to atherosclerosis, thrombosis, and vascular biology

被引:92
作者
Wickline, SA
Neubauer, AM
Winter, P
Caruthers, S
Lanza, G
机构
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[2] Philips Med Syst, Best, Netherlands
[3] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
关键词
nanotechnology; contrast agents; imaging; drug therapy;
D O I
10.1161/01.ATV.0000201069.47550.8b
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The role of nanotechnology in cardiovascular diagnosis is expanding rapidly. The goal of this brief review is to illustrate selected examples of nanosystems that have been applied to the arenas of atherosclerosis, thrombosis, and vascular biology. The technologies for producing targeted nanosystems are multifarious and reflect end uses in many cases. The results to date indicate rapid growth of interest and capability in the field. The future of cardiovascular diagnosis already is being impacted by nanosystems that can both diagnose pathology and treat it with targeted delivery systems.
引用
收藏
页码:435 / 441
页数:7
相关论文
共 66 条
[51]  
Ruehm SG, 2001, CIRCULATION, V103, P415
[52]   Pharmacokinetics and enhancement patterns of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores [J].
Sato, N ;
Kobayashi, H ;
Hiraga, A ;
Saga, T ;
Togashi, K ;
Konishi, J ;
Brechbiel, MW .
MAGNETIC RESONANCE IN MEDICINE, 2001, 46 (06) :1169-1173
[53]   Superparamagnetic iron oxide-enhanced MRI of atherosclerotic plaques in Watanabe hereditable hyperlipidemic rabbits [J].
Schmitz, SA ;
Coupland, SE ;
Gust, R ;
Winterhalter, S ;
Wagner, S ;
Kresse, M ;
Semmler, W ;
Wolf, KJ .
INVESTIGATIVE RADIOLOGY, 2000, 35 (08) :460-471
[54]   Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging [J].
Sipkins, DA ;
Cheresh, DA ;
Kazemi, MR ;
Nevin, LM ;
Bednarski, MD ;
Li, KCP .
NATURE MEDICINE, 1998, 4 (05) :623-626
[55]   Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance Imaging [J].
Sirol, M ;
Itskovich, VV ;
Mani, V ;
Aguinaldo, JGS ;
Fallon, JT ;
Misselwitz, B ;
Weinmann, HJ ;
Fuster, V ;
Toussaint, JF ;
Fayad, ZA .
CIRCULATION, 2004, 109 (23) :2890-2896
[56]   Molecular magnetic resonance imaging of atrial clots in a swine model [J].
Spuentrup, E ;
Fausten, B ;
Kinzel, S ;
Wiethoff, AJ ;
Botnar, RM ;
Graham, PB ;
Haller, S ;
Katoh, M ;
Parsons, EC ;
Manning, WJ ;
Busch, T ;
Günther, RW ;
Buecker, A .
CIRCULATION, 2005, 112 (03) :396-399
[57]   Neovascularization in atherectomy specimens from patients with unstable angina: Implications for pathogenesis of unstable angina [J].
Tenaglia, AN ;
Peters, KG ;
Sketch, MH ;
Annex, BH .
AMERICAN HEART JOURNAL, 1998, 135 (01) :10-14
[58]   In vivo detection of macrophages in human carotid atheroma - Temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI [J].
Trivedi, RA ;
U-King-Im, JM ;
Graves, MJ ;
Cross, JJ ;
Horsley, J ;
Goddard, MJ ;
Skepper, JN ;
Quartey, G ;
Warburton, E ;
Joubert, I ;
Wang, LQ ;
Kirkpatrick, PJ ;
Brown, J ;
Gillard, JH .
STROKE, 2004, 35 (07) :1631-1635
[59]  
Tsien RY, 2003, NAT CELL BIOL, pSS16, DOI 10.1038/nrm1196
[60]   Nanotechnology for molecular imaging and targeted therapy [J].
Wickline, SA ;
Lanza, GM .
CIRCULATION, 2003, 107 (08) :1092-1095