Therapeutic inhibition of tumour necrosis factor α in patients with heart failure:: cooling an inflamed heart

被引：23

作者：

Henriksen, PA ^{[1
]}

Newby, DE ^{[1
]}

机构：

[1] Univ Edinburgh, Dept Cardiol, Royal Infirm, Edinburgh EH3 9YW, Midlothian, Scotland

来源：

HEART | 2003年 / 89卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1136/heart.89.1.14

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure is a systemic disorder characterised by tissue hypoxia and secondary organ dysfunction which occurs in response to various myocardial insults that include schaemia, viral infections, and toxins. In addition to maladaptive neurohumoral activation, heart failure is associated with an inflammatory state that appears to have a detrimental effect on cardiac function and prognosis. This has led to the suggestion that anti-inflammatory interventions may have therapeutic potential in the symptomatic and prognostic treatment of patients with heart failure. This review considers the role of inhibition of the cytokine tumour necrosis factor a in the treatment of heart failure.

引用

页码：14 / 18

页数：5

共 47 条

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