Epigenetic changes and liver carcinogenesis

被引:1
作者
Peyrin-Biroulet, Laurent
Barraud, Helene
Darfeuil, Fabien
Lefebvre, Mathieu
Bigard, Marc-Andre
Gueant, Jean-Louis
Bronowicki, Jean-Pierre
机构
[1] CGU Nancy, INSERM, U724, Serv Hepatogastroenterol, Vandoeuvre Les Nancy, France
[2] CGU Nancy, INSERM, U724, Lab Pathol Cellulaire & Mol Nutr, Vandoeuvre Les Nancy, France
来源
GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE | 2006年 / 30卷 / 12期
关键词
D O I
10.1016/S0399-8320(06)73554-0
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The molecular mechanisms involved in liver carcinogenesis are poorly understood. Over the past decade, epigenetic changes (DNA methylation) have received increasing attention for their potential involvement in the development of hepatocarcinoma. The DNA methylation level is influenced by environmental factors (folate and methionine diet), as well as by genetic factors (methylenetetrohydrofolate reductase/MTHFR polymorphisms). These findings provide new insight into the understanding of liver carcinogenesis. Interventional studies are now required to determine the role of folate supplementation in the development of liver tumors in targeted patients.
引用
收藏
页码:1354 / 1359
页数:6
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