Response inhibition among early adolescents prenatally exposed to tobacco: An fMRI study

被引：33

作者：

Bennett, David S. ^{[1
]}

Mohamed, Feroze B. ^{[2
]}

Carmody, Dennis P. ^{[3
]}

Bendersky, Margaret ^{[3
]}

Patel, Sunil ^{[1
]}

Khorrami, Maryam ^{[2
]}

Faro, Scott H. ^{[2
]}

Lewis, Michael ^{[3
]}

机构：

[1] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA

[2] Temple Univ, Sch Med, Philadelphia, PA 19122 USA

[3] Robert Wood Johnson Med Sch, Newark, NJ USA

来源：

NEUROTOXICOLOGY AND TERATOLOGY | 2009年 / 31卷 / 05期

关键词：

Cocaine; Executive functioning; Functional magnetic resonance imaging; Prenatal exposure; Response inhibition; DEFICIT HYPERACTIVITY DISORDER; MATERNAL SMOKING; BEHAVIORAL-INHIBITION; SELECTIVE ATTENTION; EXECUTIVE FUNCTIONS; NICOTINE EXPOSURE; COCAINE EXPOSURE; BRAIN ACTIVATION; CONDUCT PROBLEMS; FETAL NICOTINE;

D O I：

10.1016/j.ntt.2009.03.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Children prenatally exposed to tobacco have been found to exhibit increased rates of behavior problems related to response inhibition deficits. The present study compared the brain function of tobacco-exposed (n = 7) and unexposed (n = 11) 12-year-olds during a Go/No-Go response inhibition task using an event-related functional MRI (fMRI) design. Prenatal alcohol exposure, neonatal medical problems, environmental risk, IQ, current environmental smoke exposure, and handedness were statistically controlled. Tobacco-exposed children showed greater activation in a relatively large and diverse set of regions, including left frontal, right occipital, and bilateral temporal and parietal regions. In contrast, unexposed but not exposed children showed activation in the cerebellum, which prior research has indicated is important for attention and motor preparation. The diversity of regions showing greater activation among tobacco-exposed children suggests that their brain function is characterized by an inefficient recruitment of regions required for response inhibition. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：283 / 290

页数：8

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