The follicular versus marginal zone B lymphocyte cell fate decision

被引：407

作者：

Pillai, Shiv ^{[1
]}

Cariappa, Annaiah

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 11期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; ANTIGEN RECEPTOR SIGNALS; IN-VIVO; BONE-MARROW; IMMUNE-RESPONSES; CORROSION CASTS; MICROCIRCULATORY PATHWAYS; POSITIVE SELECTION; SURVIVAL SIGNALS; DISTINCT ROLES;

D O I：

10.1038/nri2656

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bone marrow-derived B cells make an important cell fate choice to develop into either follicular B cells or marginal zone B cells in the spleen, which depends on signalling through the B cell receptor, Notch2, the receptor for B cell-activating factor and the canonical nuclear factor-kappa B pathway, as well as signals involved in the migration and anatomical retention of marginal zone B cells. Recent information discussed in this Review reconciles some of the controversies regarding the role of the B cell receptor in this cell fate decision and a clearer picture has also emerged regarding the anatomical location of ligands for Notch2 in the spleen. This cell fate decision could provide mechanistic insights that are relevant to other commitment events in lymphocytes.

引用

页码：767 / 777

页数：11

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