Immunotherapy for AIDS virus infections: Cautious optimism for cell-based vaccine

被引：11

作者：

Bhardwaj, N ^{[1
]}

Walker, BD

机构：

[1] NYU, New York, NY 10003 USA

[2] Rockefeller Univ, New York, NY 10021 USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Partners AIDS Res Ctr, Boston, MA USA

[4] Harvard Univ, Div Aids, Sch Med, Boston, MA USA

来源：

NATURE MEDICINE | 2003年 / 9卷 / 01期

关键词：

D O I：

10.1038/nm0103-13

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A vaccine that is able to work as a treatment for HIV-infected patients has been an elusive goal. Now experiments on macaques suggest that injections of modified dendritic cells might boost immunity to hold back disease progression (pages 27–32).

引用

页码：13 / 14

页数：2

共 16 条

[1] HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus [J].

Altfeld, M ;

Allen, TM ;

Yu, XG ;

Johnston, MN ;

Agrawal, D ;

Korber, BT ;

Montefiori, DC ;

O'Connor, DH ;

Davis, BT ;

Lee, PK ;

Maier, EL ;

Harlow, J ;

Goulder, PJR ;

Brander, C ;

Rosenberg, ES ;

Walker, BD .

NATURE, 2002, 420 (6914) :434-439

[2] Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection [J].

Altfeld, M ;

Rosenberg, ES ;

Shankarappa, R ;

Mukherjee, JS ;

Hecht, FM ;

Eldridge, RL ;

Addo, MM ;

Poon, SH ;

Phillips, MN ;

Robbins, GK ;

Sax, PE ;

Boswell, S ;

Kahn, JO ;

Brander, C ;

Goulder, PJR ;

Levy, JA ;

Mullins, JI ;

Walker, BD .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (02) :169-180

[3] Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[4] Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes [J].

Barouch, DH ;

Kunstman, J ;

Kuroda, MJ ;

Schmitz, JE ;

Santra, S ;

Peyerl, FW ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Gorgone, DA ;

Montefiori, DC ;

Lewis, MG ;

Wolinsky, SM ;

Letvin, NL .

NATURE, 2002, 415 (6869) :335-339

[5] INACTIVATED INFLUENZA-VIRUS, WHEN PRESENTED ON DENDRITIC CELLS, ELICITS HUMAN CD8(+) CYTOLYTIC T-CELL RESPONSES [J].

BENDER, A ;

BUI, LK ;

FELDMAN, MAV ;

LARSSON, M ;

BHARDWAJ, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) :1663-1671

[6] SMALL AMOUNTS OF SUPERANTIGEN, WHEN PRESENTED ON DENDRITIC CELLS, ARE SUFFICIENT TO INITIATE T-CELL RESPONSES [J].

BHARDWAJ, N ;

YOUNG, JW ;

NISANIAN, AJ ;

BAGGERS, J ;

STEINMAN, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :633-642

[7] Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells [J].

Dhodapkar, MV ;

Steinman, RM ;

Sapp, M ;

Desai, H ;

Fossella, C ;

Krasovsky, J ;

Donahoe, SM ;

Dunbar, PR ;

Cerundolo, V ;

Nixon, DF ;

Bhardwaj, N .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (02) :173-180

[8] Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques [J].

Jin, X ;

Bauer, DE ;

Tuttleton, SE ;

Lewin, S ;

Gettie, A ;

Blanchard, J ;

Irwin, CE ;

Safrit, JT ;

Mittler, J ;

Weinberger, L ;

Kostrikis, LG ;

Zhang, LQ ;

Perelson, AS ;

Ho, DD .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (06) :991-998

[9] Therapeutic dendritic-cell vaccine for simian AIDS [J].

Lu, W ;

Wu, XX ;

Lu, YZ ;

Guo, WZ ;

Andrieu, JM .

NATURE MEDICINE, 2003, 9 (01) :27-32

[10]

Ludewig B, 1999, J IMMUNOL, V163, P1839

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