Total synthesis of (+)-aspidospermidine: A new strategy for the enantiospecific synthesis of aspidosperma alkaloids

被引：115

作者：

Marino, JP ^{[1
]}

Rubio, MB ^{[1
]}

Cao, GF ^{[1
]}

de Dios, A ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 45期

关键词：

D O I：

10.1021/ja026357f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy was developed for the enantiospecific synthesis of aspidosperma alkaloids. The key steps involve a novel ketene-lactonization reaction of a chiral vinyl sulfoxide to efficiently set up the quaternary carbon center, and a tandem Michael addition-alkylation reaction sequence to form the polycyclic core structure. This new strategy was employed in the total synthesis of natural product (+)-aspidospermidine. Copyright © 2002 American Chemical Society.

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页码：13398 / 13399

页数：2

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