Efficient phosphodiester binding and cleavage by a ZnII complex combining hydrogen-bonding interactions and double lewis acid activation

被引：137

作者：

Feng, Guoqiang

Natale, Daniela

Prabaharan, Ravi

Mareque-Rivas, Juan C.

Williams, Nicholas H.

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

[2] Univ Sheffield, Dept Chem, Ctr Chem Biol, Sheffield S3 7HF, S Yorkshire, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 42期

基金：

英国生物技术与生命科学研究理事会;

关键词：

dinuclear complexes; enzyme models; hydrogen bonds; phosphate ester cleavage; receptors;

D O I：

10.1002/anie.200602532

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A combined attack: Hydrogen-bonding interactions with double Lewis acid activation generate a dinuclear ZnII complex that is exceptionally effective for binding monoanionic phosphate diesters in water and for catalyzing phosphodiester transesterifications. The complex catalyzes the hydrolytic cleavage of RNA-like activated, artificial substrates and nonactivated, natural substrates with similar efficiencies. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7056 / 7059

页数：4

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