Porrigenins A and B, novel cytotoxic and antiproliferative sapogenins isolated from Allium porrum

被引：38

作者：

Carotenuto, A

Fattorusso, E

Lanzotti, V

Magno, S

DeFeo, V

Carnuccio, R

DAcquisto, F

机构：

[1] UNIV NAPLES FEDERICO II,DIPARTIMENTO CHIM SOSTANZE NAT,I-80131 NAPLES,ITALY

[2] UNIV MOLISE,DIPARTIMENTO SCI & TECNOL AGROALIMENTARI AMBIENTA,I-86100 CAMPOBASCO,ITALY

[3] UNIV SALERNO,FAC FARM,I-84084 PENTA,SALERNO,ITALY

[4] UNIV NAPLES FEDERICO II,DIPARTIMENTO FARMACOL SPERIMENTALE,I-80131 NAPLES,ITALY

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 10期

关键词：

D O I：

10.1021/np960657r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new sapogenins, porrigenins A (2a) and B (3a), identified as (25R)-5 alpha-spirostan-2 beta,3 beta,6 beta-triol and (25R)-2-oxo-5 alpha-spirostan-3 beta,6 beta-diol, respectively, and neoporrigenins A (2b) and B (3b) were also isolated from Allium porrum. In addition, the known agigenin (1a) and its 25S epimer, neoagigenin (1b), were also identified. Their structure elucidation was provided by comprehensive spectroscopic analyses. Compounds 1a, 2a, and 3a exhibited cytotoxicity and high antiproliferative acivity on four different tumor cell lines in vitro.

引用

页码：1003 / 1007

页数：5

共 14 条

[1] C-13 NMR SPECTRAL INVESTIGATIONS .10. C-13 NMR-SPECTROSCOPY OF STEROIDAL SAPOGENINS AND STEROIDAL SAPONINS [J].